I like most people out there hate pop-up ads. If you want to put one on your site to generate $$$ then more power to you. But unless they have some great content I won't be back to that site.
As for pop-up killers. I have tried them some of them get the job done but i still see it try to pop-up and it closes real fast yeah but it's still annoying. Not only that but there is another program thats installed on my computer.
I would never have a pop-up on my site as well.