I could see a site wide user ignore feature. Similar to banning. Only admins (and maybe mods) could see posts that a site-wide ignored user made. Others wouldn't see them.
Now if you gave users the option to ignore specific users... that would be great. And we've talked about this. But the tough part becomes how you deal with the thread in threaded view. If you have ignored a user... how do you deal with a broken thread?
Or do you see a generic post with **ignored** in the body as a placeholder so that threads don't get broken. ???