Longer times are better if you don't mind information being displayed that's not quite "up to date". Use odd numbers for the minutes to cut down on overlap. Some things such as the "news" section could be changed every 12 hours (720 minutes) and if you need to bring a news article to the front then just add &RefCache=1 to the url or ?RefCache=1 if you have a Cat= in the url.
Pull the polls out of just one forum. Don't make it random.
Turn "force public" on. This is needed if your going to cache the news.
If you really don't need a particular pal box turning it off will help.
These are all I can think of at the moment. Might be one or two more if I think about it long enough... lol
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