As far as Photopost many things. You can see the many changes on their site.
Basically if you are updating Photopost then you update it and reapply this mod by doing the following to upgrade
1. reapply the hack part to pp-inc.php and adm-inc.php
2. Upload the modified 4.6 templates
As you upgrade each version of Photopost you need to reapply at lease this portion of the mod as pp-inc.php changes with each version and the templates as they change also.
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